Metastasis is the spread of cancer cells from other organs to bone typically from prostate cancer, lung, and breast cancer to bone.
The process of bone metastases occur in three basic mechanisms, as follows:1. Expansion directly
2. Following the flow of venous blood
3. Following tumor emboli through the bloodstream and lymphatic
The process of bone metastases occur in three basic mechanisms, as follows:1. Expansion directly
2. Following the flow of venous blood
3. Following tumor emboli through the bloodstream and lymphatic
Here is the basic mechanism of metastasis process:1. Cells from the primary tumor to follow the flow of the blood vessels to the capillaries in the bone.
2. Aggregation between tumor cells and other blood cells to form capillary embolism in the distal part of the bone.
3. Upon entering the bone, the cancer cells will begin to flourish.
4. Cancer cells that have spread to the bones can cause severe bone damage.
5. Tumor cells secrete chemical substances that can stimulate osteoclast-like prostaglandin E (PGE), several types of cytokines, and growth factors such as (TGF) α and β, epidermal growth factor (EGF), (TNF), and IL-1.
6. Excessive osteoclast will cause excessive bone resorption as well. This causes the bones are not solid. This process is called osteolytic. This process occurs in the process of bone metastases by breast cancer.
7. Tumor cells can also secrete chemical substances that can cause uncontrolled bone formation. This process is called osteoblastic or osteosklerotik. Examples of this process is metastasis to bone by prostate cancer. Both of these types of disorders can cause pain and weaker than normal bone so that it becomes easier to break.
2. Aggregation between tumor cells and other blood cells to form capillary embolism in the distal part of the bone.
3. Upon entering the bone, the cancer cells will begin to flourish.
4. Cancer cells that have spread to the bones can cause severe bone damage.
5. Tumor cells secrete chemical substances that can stimulate osteoclast-like prostaglandin E (PGE), several types of cytokines, and growth factors such as (TGF) α and β, epidermal growth factor (EGF), (TNF), and IL-1.
6. Excessive osteoclast will cause excessive bone resorption as well. This causes the bones are not solid. This process is called osteolytic. This process occurs in the process of bone metastases by breast cancer.
7. Tumor cells can also secrete chemical substances that can cause uncontrolled bone formation. This process is called osteoblastic or osteosklerotik. Examples of this process is metastasis to bone by prostate cancer. Both of these types of disorders can cause pain and weaker than normal bone so that it becomes easier to break.
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